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KMID : 0361420020260030292
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Journal of Korean Academy of Rehabilitation Medicine
2002 Volume.26 No. 3 p.292 ~ p.298
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The Effect of Sympathetic Nervous System and Oxybutynin to Colon Transit Time in Spinal Cord Injured Patients
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신지철/Ji Cheol Shin
박창일/김정은/이병호/나동욱/Chang Il Park/Jung Eun Kim/Byung Ho Lee/Dong Wook Na
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Abstract
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Objective: The aims of this study is to determine the influence of the imbalance between sympathetic and parasympathetic nervous input to colon transit control in spinal cord injured patients and the effect of the anticholinergic medication
for
neurogenic bladder on colon transit time.
Method: Eighty-six patients with cervical and thoracic cord injury were enrolled. The colon transit time (CTT) according to the severity and lesion of injury and also the administration routes of oxybutynin were compared by independent
t-test.
Results: Total CTT was 56.7 hours, with right CTT 16.9 hours, left CTT 21.3 hours and rectosigmoid CTT 18.5 hours. The rectosigmoid CTT of the patients with the lesion at T6 or below were prolonged than that of the patients with the lesion
above
T6 (p＜0.05). According to administration route of oxybutynin, instillation group showed more shortened rectosigmoid CTT than oral route group (p＜0.05).
Conclusion: The imbalance between parasympathetic and sympathetic outflow from the spinal cord has play an important role in colon transit control of spinal cord injured patients. The management of neurogenic bowel and bladder considering
colon
transit time is needed for the effective management of spinal cord injured patients.
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